Derek Lowe on CRISPR, from the comments

By Tyler Cowen


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from Marginal REVOLUTION.

Derek writes:

As a scientist in the biopharma world, I can tell you this this does indeed seem very close to being done in humans, and that there is a very high (but still not perfect) chance of success. CRISPR/Cas9 is the real deal, and there are others competing for its spot as well (such as zinc-finger TALEN technology, whose discoverers have just called for a similar moratorium on human germ-line work). There’s no need to whisper about possible Nobel Prizes in this area – the only difficulty for the Nobel committees will be figuring out how to divide the credit and who exactly to recognize.

The first human applications would surely be the obvious single-mutation genetic diseases. In most cases, this would be done best as germ-line work, followed by in vitro fertilization. The children born after such a process would, of course, pass their altered/repaired DNA to their own offspring, and it’s this possibility that has people worried, in case we get it wrong, or in case we start messing around for more arguable traits. (Fixing these problems after you’ve become a fully sized human is harder, because you have to find a way to treat enough cells in the body to make a lasting difference).

Many of the possibilities that people are most worried about are harder to pin down, though. There’s no single gene for height, for example, or intelligence (or Alzheimer’s or diabetes, for that matter, to stick with the fixing-what’s-broken part of the landscape). Many of the really sticky issues are still a bit downstream, awaiting a better understanding of the human genome, but the big fundamental one is indeed here now: the first deliberate editing of the human genetic inheritance. Tyler’s absolutely right about that one – it could be done right now by anyone with the nerve to do it.

Here is Derek’s website.

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#WordsMatter: Obama's 2008 AIPAC speech sounded a lot like Bibi's 2015 Congress speech

By Elder of Ziyon (noreply@blogger.com)


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from Elder Of Ziyon – Israel News.

From the

Yes, Josh Earnest, words matter. Too bad your boss tramples on that principle.

Too bad none of Obama’s fans who claim to be pro-Israel are willing to hold the president to his own standards.

(h/t EBoZ, see also Joe Settler)

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